Specialty billing
Laboratory billing services
Laboratory billing is coding and claiming each test a lab runs with the diagnosis that justifies it, the provider who ordered it and the lab’s CLIA number, so the payer can match the test to its order.
Laboratory
What a lab claim carries
- The orderNPIThe ordering provider, enrolled in Medicare
- The labCLIAA certificate that covers the test; QW if waived
- The diagnosisICD-10GAOn the covered list, or an ABN signed
Try it
Check what a lab claim needs
The order, the lab’s certificate and the diagnosis each put something on the claim.
What does this lab claim need?
Medicare and othersTick what is true for the test.
The claim carries
- 1The ordering provider’s NPI, matching the order
- 2An ordering provider enrolled in Medicare
- 3The lab’s CLIA number, on a certificate that covers the test
- 4Modifier GA: the patient signed an ABN, so they can be billed if Medicare denies it
Why is laboratory billing hard?
Coverage depends on the diagnosis
For many tests, Medicare and other payers list the diagnoses they cover. A test ordered with a diagnosis outside that list is denied, and a Medicare patient can be billed for it only if they signed an Advance Beneficiary Notice before the test.
Every claim carries the order
A lab claim names the provider who ordered the test, by NPI, and Medicare denies it when that provider isn’t enrolled in Medicare. The order’s details have to match what the claim says.
CLIA rules on every test
Medicare claims for lab tests carry the lab’s CLIA certificate number, and the certificate has to cover the test billed. Waived tests billed to Medicare need the QW modifier.
Two sets of drug testing codes
Presumptive drug screens are billed with 80305–80307, and definitive tests by the number of drug classes: G0480–G0483 for Medicare, 80320–80377 for many other payers. Payers also limit how often each is paid.
Molecular tests need more than a code
Molecular tests have their own CPT codes (81105–81479) and proprietary laboratory analysis codes ending in U, and some Medicare contractors also want the lab’s test registered with an identifier before they pay.
What Beeline handles for laboratories
- Medical codingEach test coded from the order and the result: panels billed as panels, the QW modifier on waived tests, and the diagnosis the order gives.
- Claims submissionCharges entered and claims built with the ordering provider’s NPI and the lab’s CLIA number, checked against the payer’s coverage rules for the diagnosis before they are sent.
- Denial managementDenials for medical necessity, missing order details or frequency limits traced to their cause, then corrected or appealed.
- A/R follow-upMany small claims followed up by payer and age, so low balances aren’t left to pass the filing limit.
- Payment postingPayments posted per test line, with lines paid below the payer’s fee schedule flagged.
Laboratory billing questions
Why does a CLIA number go on a lab claim?
What is an Advance Beneficiary Notice for lab tests?
What is the difference between presumptive and definitive drug testing?
Find out where your laboratory billing stands.
Unsure how much revenue you are missing? Start with a complimentary billing audit.
Free consultation

